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crosscountrygal_5 asked Does variation occur in offspring during mitosis?
Does variation occur in offspring during meiosis?
And got the following answer:
In general, no, mutations don't occur during mitosis. At least they are not supposed to. For a more complicated answer, yes they do occur. The polymerase that replicates the DNA is reported to make a mistake on approximately every millionth nucleotide it encounters. The human genome is really big, and so, lots of mistakes can occur. Here is one example: Polymerases especially makes mistakes in areas where the DNA sequence is "enriched" with T's and A's (these are called TA repeats). TATATATATATATATATAT(x100, but I won't type all that) is a sequence where a DNA polymerase can "slip off" of the strand and lose its place during replication. The typical consequence of this is the DNA ends up with extra TA repeats. It is not difficult to imagine how the polymerase can make mistakes within a TA repeat region of the chromosome. If you will bear with me, I'd like to explain it to you. It helps to imagine DNA as a 3 dimensional object. I like to think of one chromosome as two spaghetti stands clinging to one another. Or you can imagine a single chromosome as a ladder. Just don't forget that it can be a very flexible molecule. You probably learned that T base pairs with A. So keep that in mind too. But during replication, the two stands become single stranded temporarily. So imagine the two spaghetti stands separating in the middle. This would be where replication is occurring. Now (and this is the really hard part to get across) imagine ONE of the spaghetti stands folding onto itself. There are all those TA repeats that were one once base pairing with AT repeats on the opposite stand. But if you had a succession of TA repeats on the same strand, its possible for them to match up with AT partners of the same strand, if that stand looped out and came within close proximity to its base pairing partner. TA with no replication occurring: STRAND 1 TATATATATATATATATATATATATAT STRAND 2 ATATATATATATATATATATATATATA This is what a TA loop looks like AT AT AT AT AT AT AT AT AT STRAND1 CTGA CGTA ATATATATAT STRAND 2 ATATATATATATATATATATATATATATATATTA The polymerase working to replicate the stand with the loops may lose its place. as I mentioned before. This exact reason as to how it loses it bearings has never been clear, but it does happen, maybe more than expected. These types of mistakes are not usually detrimental in somatic cells (cells only capable of mitosis [which is the majority of our cells]). Specialized cells (sex cells) are another story: Researchers have concluded that some diseases are directly linked to extra TA repeats in the genome of sex cells (cells that perform meiosis). In fact, many important genetic variations (good and bad) most often occur during meiosis. Nature actually encourages it to happen within these cells. This is the opportunity for Mom's DNA and Dad's DNA to switch up long segments of their DNA. What I mean is, long segments of Dad's DNA will end up on Mom's DNA, and vice-versa. Scientists believe this greatly adds to the diversity of the offspring (You), and may limit the potential mutations found on one chromosome alone (by at least giving YOU one woking copy of a gene). It does have its downfalls too. One theoretical point to keep in mind (and this is classical old school genetics and this viewpoint challenged often): Variation doesn't matter so much in somatic cells (cells which only go through mitosis), because they eventually die off. The variations that occur in sex cells will be passed on to the next generation. I hope I didn't overwhelm you with my yes and no answer, but it is comphrehensive. Take from it what you wish. Spread the Karma!!